全球共识声明 关于在炎症性肠病中管理怀孕
Uma Mahadevan1, Cynthia H Seow2, Edward L Barnes3
1Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California, USA.
The American journal of gastroenterology
|August 27, 2025
概括
这项研究为怀孕期间的炎症性肠病 (IBD) 提供了全球指导,旨在通过巩固专家对孕妇IBD治疗的建议来改善母亲和婴儿的结果.
科学领域:
- 胃肠病学和肝病学
- 产科和妇科
- 免疫学
背景情况:
- 由于药物安全性研究和数据有限,孕妇患有炎症性肠病 (IBD) 面临重大挑战.
- 患者和提供者缺乏全面的知识,导致护理实践变化,影响怀孕率,药物坚持以及孕产妇和胎儿的结果.
- 国际准则的矛盾使医生和患者的管理决策更加复杂.
研究的目的:
- 建立全球共识,并为患有IBD的孕妇提供数据驱动的实践指导.
- 解决知识缺口和标准化在怀孕期间管理IBD的最佳实践.
- 改善全世界IBD妇女的妊娠结果和孕产妇健康.
主要方法:
- 一个由39名IBD专家和7名患者倡导者组成的全球共识联盟召开了审查现有数据的会议.
- 在存在足够数据的情况下,使用GRADE方法进行基于证据的建议.
- 对于缺乏可靠的公布数据的领域,使用了RAND过程.
主要成果:
- 该联盟讨论了10个关键主题类别,这些主题与怀孕期间的IBD治疗有关.
- 根据现有证据,共制定了34项GRADE建议.
- 在数据有限的临床实践中,制定了共识陈述.
结论:
- 这份指南旨在在全球范围内规范和加强对有IBD的孕妇的护理.
- 这些建议将母亲健康作为支持婴儿健康的关键.
- 这项倡议旨在减少怀孕期间IBD的混乱,并提高治疗的一致性.
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