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免疫疗法试验中的固体瘤患者的调节治疗结果:一期单元的药物相互作用分析

Camila Braganca Xavier¹, Clark R Andersen², JoAnn Lim¹

¹The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Cancer research communications

|August 27, 2025

概括

同时使用的药物会影响免疫治疗的有效性. 抗胰岛素改善了免疫调节剂和抗体的结果,而质子抑制剂则缩短了接受免疫治疗的结直肠癌患者的生存期.

科学领域:

癌症学
临床药理学
癌症治疗方法

背景情况:

同时使用药物可能会影响免疫疗法的有效性,这是免疫检查点抑制剂的已知相互作用.
同时使用的药物对新型试验性免疫疗法的影响在很大程度上尚未评估.

研究的目的:

在早期免疫疗法试验中研究并发药物对患者结果的影响.
确定可能调节研究癌症疗法的特定药物类别.

主要方法:

在早期试验中接受免疫治疗的897名患者的回顾性分析.
通过计算机数据提取,确定了在免疫治疗输注后30天内处方的并发药物.
主要终点包括中位数整体存活率 (OS) 和无进展存活率,瘤反应通过RECIST进行评估.

主要成果:

与免疫调节剂和抗体相结合时,抗组胺使用与改善的稳定性疾病和部分反应率有关 (P=0. 014).
在多变量分析中,抗胰岛素对整体存活率有好处 (HR=0. 752,P=0. 012).
在结直肠癌患者中使用质子抑制剂 (PPI) 与中位寿命显著缩短 (5. 2个月与PPI相比8. 6个月,P< 0. 001).

结论:

在早期免疫疗法试验中,同时选择药物需要进行战略性考虑.
抗胰岛素可能会提高免疫疗法的有效性,而PPI可能会对某些癌症类型 (如结肠直肠癌) 的存活率产生负面影响.

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