与隐性听力损失相关的睡眠障碍:人类数据和小鼠睡眠碎片模型的见解
Xiaodi Wang1, Bo Su1, Jiaxin Zhang1
1Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
Brain and behavior
|August 27, 2025
概括
睡眠碎片造成细微的听觉神经和内毛细胞突触损伤, 这表明睡眠不足与隐性听力损失之间存在联系.
科学领域:
- 神经科学
- 听觉科学
- 睡眠医学
背景情况:
- 睡眠障碍与听力功能障碍有关.
- 睡眠碎片 (SF) 对外周听力系统的具体影响尚不清楚.
研究的目的:
- 研究睡眠障碍与噪音环境中的语音感知困难之间的关联.
- 使用小鼠模型检查SF对听觉功能和耳病理的影响.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据.
- 在SF小鼠模型中进行听觉脑干反应 (ABR) 测试.
- 耳组织的免疫光染色和传输电子显微镜.
主要成果:
- 患有睡眠障碍和正常听力图的人报告说,在噪音中听到语音有所增加.
- 在没有值变化的情况下,SF小鼠显示ABR波I幅度降低和延长的延迟.
- 导致内毛细胞带突触的减少和听觉神经纤维中的髓损伤.
结论:
- 睡眠碎片化会导致亚临床听力系统损伤,影响突触和神经纤维.
- 这种损伤可能解释了噪音环境中的语音识别困难.
- 由SF引起的听力变化是潜在的隐性听力损失指标.
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