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Updated: Sep 10, 2025

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
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Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Published on: November 9, 2020

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在FAHN中破坏了髓化:来自患者特异的hiPSC神经元-寡细胞模型的见解

Fatima Efendic1, Andreas Hermann1,2,3, Moritz J Frech1,2

  • 1Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.

Cells
|August 27, 2025
PubMed
概括

脂肪酸基酶相关的神经退行 (FAHN) 是一种罕见的遗传性疾病. 这项研究使用患者衍生的干细胞来建模FAHN,揭示了髓缺陷和自功能障碍,建议新的治疗点.

关键词:
其他:美国自食症脱髓化诱导多能干细胞骨髓蛋白质神经元体细胞

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相关概念视频

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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