在路易斯安那州通过环境风险因素调查前列腺癌诊断阶段差异的调解分析
Nubaira Rizvi1, Randy Hamilton1, Xiao-Cheng Wu2
1Biostatistics and Data Science, School of Public Health, LSU Health-New Orleans, New Orleans, LA 70112, USA.
Current oncology (Toronto, Ont.)
|August 27, 2025
概括
环境和个人因素对前列腺癌诊断阶段的种族差异有很大影响. 解决工业污染对于减少黑人差异至关重要.
科学领域:
- 环境健康
- 癌症流行病学
- 健康上的差异
背景情况:
- 前列腺癌 (PCa) 是男性癌症死亡的主要原因,在诊断阶段存在显著的种族差异.
- 在路易斯安那州,与高加索裔美国人 (CA) 相比,非洲裔美国人 (AA) 在晚期被诊断患有PCa.
研究的目的:
- 探索环境风险因素作为将种族与PCa诊断阶段联系起来的潜在中间变量.
- 量化个人和环境因素对PCa诊断阶段的种族差异的贡献.
主要方法:
- 利用路易斯安那州瘤登记处在2010年至2018年间诊断的24647名男性PCa患者的数据.
- 使用多重添加回归树 (MART) 的调解分析来识别中间变量.
- 分析的个人特征 (BMI,婚姻状况,并发症等) 和环境因素 (空气毒性,乙,喘发病率等). ) 的情况.
主要成果:
- 在PCa阶段,个体特征解释了84%的种族差异.
- 环境因素共同解释了种族差异的18.6%.
- 关键的环境因素包括空气毒性,喘患病率和乙化物水平.
结论:
- 个人和环境因素在PCa诊断阶段的种族差异中起着重要作用.
- 环境因素,特别是工业污染物,是干预的关键目标.
- 解决空气毒性和相关因素对于减少PCa诊断差异至关重要.
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