从2000年到2020年,前列腺癌发病率和生存率的趋势:意大利东北部的人口研究
在PubMed上查看摘要
概括
此摘要是机器生成的。前列腺癌的发病率有所转变,低级癌症的诊断率下降,但高级癌症的比例上升,特别是在老年男性中. 所有格里森分数的生存率都有所提高,但这种趋势需要量身定制的临床策略.
科学领域
- 癌症学
- 流行病学
- 公共卫生
背景情况
- 前列腺癌 (PCa) 趋势受到不断发展的查实践的影响.
- 本研究通过格里森评分 (GS) 检查意大利东北部的长期PCA发病率和生存率.
研究的目的
- 评估PCa发生率和存活率的时间趋势.
- 通过格里森分数和年龄组来分析这些趋势.
主要方法
- 从区域癌症登记处对21571个PCa病例 (2000-2020年) 的基于人口的研究.
- 按年龄标准化的发病率和5年生存率 (总和净) 按GS (2-6,7,8-10) 和年龄计算.
- 用Joinpoint回归进行趋势分析.
主要成果
- 在2007年之前,PCa的发病率上升,然后在2010年急剧下降,然后稳定下来.
- 低度PCa (GS2- 6) 的发病率在所有年龄段都下降,特别是在75岁以上的男性中.
- 高度PCa (GS 8-10) 的发病率保持稳定,但其比例从20%增加到29%,特别是在老年男性中.
- 所有GS组的生存率都有所改善;在GS7和GS8-10的老年男性中观察到显著的增长.
结论
- 整体PCA结果有所改善.
- 尤其是在老年男性中, 高度PCa的比例越来越高, 是令人担忧的.
- 需要量身定制的临床策略来应对这些不断变化的趋势.
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