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人类测量和摩洛哥妇女患乳腺癌的风险:一项大型多中心病例对照研究
Najia Mane1,2, Najoua Lamchabbek2,3, Siham Mrah4
1Laboratory of Epidemiology and Research in Health Sciences, Pharmacy and Dental Medicine, Faculty of Medicine, Sidi Mohamed Ben Abdallah University, Fez 30070, Morocco.
Current oncology (Toronto, Ont.)
|August 27, 2025
概括
腰部和部周长等肥胖指标增加了绝经前和绝经后摩洛哥妇女患乳腺癌的风险. 根据更年期的状态,身体质量指数 (BMI) 和不同生命阶段的体重也与BC风险存在不同的关联.
科学领域:
- 癌症学
- 流行病学
- 公共卫生
背景情况:
- 肥胖是已知的更改性乳腺癌 (BC) 的风险因素.
- 脂肪和更年期前BC风险之间的关联不太清楚.
- 摩洛哥人口中这种关系的数据有限,特别是关于更年期状态的数据.
研究的目的:
- 研究摩洛哥妇女的各种肥胖指标与乳腺癌 (BC) 风险之间的联系.
- 根据更年期状态 (更年期前与更年期后) 检查潜在的差异关系.
主要方法:
- 在摩洛哥进行的多中心病例控制研究 (2019年12月至2023年8月).
- 包括1400个事件BC病例和1400个匹配的对照.
- 收集生命阶段的详细人体测量和自我报告数据;使用无条件后勤回归进行分析.
主要成果:
- 在更年期前和更年期后的妇女中,腰围 (WC) 和部周围 (HC) 的增加与更高的BC风险有关.
- 当前高体重指数 (BMI) (≥30 kg/ m2) 与更年期后的BC风险增加有关.
- 20岁和30岁的体重和年轻成年人BMI在两组中都显示出BC风险趋势的增加;20岁以后的体重增加显示出更年期后妇女的反向关联.
结论:
- 在摩洛哥妇女中,人体测量因素与绝经前和绝经后的乳腺癌风险有不同的关联.
- 这些发现突出了与BC风险相关的不同生命阶段的肥胖的重要性.
- 需要进一步的大规模前性研究来阐明这些关联及其分子联系.
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