基于人口的美国心血管疾病死亡率的性别差异研究,2000-2021年
Duke Appiah1, Abdulkader Almosa2, Eli Heath3
1Julia Jones Matthews School of Population and Public Health, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Current oncology (Toronto, Ont.)
|August 27, 2025
概括
被诊断为眼癌的男性面临更高的心血管疾病 (CVD) 死亡风险,特别是那些在65岁之前被诊断的男性. 针对性心血管干预对于改善这一患者群的存活率至关重要.
科学领域:
- 癌症学
- 心脏病学
- 流行病学
背景情况:
- 眼癌患者的心血管疾病 (CVD) 症状尚未得到充分研究.
- 目前关于OC患者的性别生存差异的报告不一致.
研究的目的:
- 评估美国OC诊断后心脏病死亡率的发生情况.
- 研究OC幸存者心血管疾病死亡率的性别差异.
主要方法:
- 利用了2000-2021年间被诊断患有OC的11,460名成年人的数据,这些数据来自监测,流行病学和最终结果 (SEER) 计划.
- 使用竞争风险模型来估计心血管疾病死亡率的危险比率 (HR) 和95%置信区间 (CI).
- 调整社会人口统计学和临床病理学因素,并进行倾向评分分析.
主要成果:
- 在平均5. 4年的随访期间,有15%的4561例死亡是由心血管疾病引起的.
- 患有OC的成年男性患心血管疾病的死亡风险较高 (HR: 1.54, 95%CI: 1. 31-1. 81).
- 在65岁前被诊断患有心血管疾病的个体中,性别差异更为明显 (HR: 2. 15; 95%CI: 1. 48-3. 11).
结论:
- 在被诊断患有OC的年轻和中年男性中,心血管疾病死亡率较高.
- 在OC诊断后实施最佳的心血管健康干预措施,尤其对男性来说,可能会提高存活率.
- 需要进一步研究以了解OC患者心血管疾病风险增加的潜在机制.
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