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Updated: Sep 10, 2025

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布利祖马布诱导的同时和耐火的系统毛细血管泄漏和细胞因子释放综合征:一个病例报告

Eugénie Roberge-Maltais1, Eric Lévesque2, Vincent Castonguay2

  • 1Department of Internal Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.

Current oncology (Toronto, Ont.)
|August 27, 2025
PubMed
概括

一名患有晚期子宫癌的妇女因PD-1抑制剂治疗而出现罕见的系统毛细血管泄漏综合征 (SCLS) 和细胞因子释放综合征 (CRS). 一种新的多模式治疗成功地控制了这些严重的不良事件.

关键词:
PD-1 抑制剂的使用亚西替尼毛细血管泄漏综合征细胞因子释放综合征免疫检查点抑制剂瑞克索利提尼

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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