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一种以 Galactose-Functionalized PyrrolopyrroleAza-BODIPY用于高效检测八种异形和芳香生物氨基:监测食品的新鲜度和生物成像

Yujing Gan¹, Bingli Lu¹, Jintian Zhong¹

¹School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510640, China.

|August 27, 2025

概括

一个新的视觉化学传感器,PPAB-Gal,可以同时检测八种生物氨基 (BA) 用于食品安全和疾病诊断. 这种传感器提供了快速,敏感和直观的结果, 改进了现有的方法.

科学领域:

分析化学
生物医学传感
材料科学

背景情况:

生物胺 (BA) 是食品腐烂,环境监测和疾病诊断的关键指标.
目前用于BA的光探测器通常缺乏灵敏度,并且难以同时检测多种氨基类型.
现有的方法显示单个信号变化,限制复杂的传感平台的适应性.

研究的目的:

开发一种新的视觉化学传感器,用于同时检测多种亚利法和芳香生物胺.
建立一个具有双色测量和比测量发射能力的传感平台,以提高灵敏度和特异性.
展示传感器在食品新鲜度评估和生物医学成像中的实际应用.

主要方法:

合成了以银河糖功能化的pyrrolopyrrole aza-BODIPY (PPAB-Gal) 作为视觉化学传感器.
该传感器利用非共价相互作用 (π-π 堆叠,键) 来实现基于染色体的双信号变化.
用智能手机辅助的薄层染色体 (TLC) 板和纳米粒子配方用于定性和定量分析.

主要成果:

通过PPAB-Gal可以同时检测出8个BA,具有明显的双色测量和比测量变化 (Δλab=130nm,Δλem=150nm).
传感器表现出优异的性能,检测极限低 (~25nM) 和快速响应时间 (<2分钟).
在视觉检测和尸体蒸气,定量评估鱼的新鲜度 (TVBN值) 和活细胞中精子素的比率成像中成功应用.

结论:

PPAB-Gal提供了一种有前途,敏感和选择性的生物胺检测方法.
开发的平台为食品安全和生物医学领域的实时现场检测提供了简单方便的方法.
这项工作为食品质量和疾病诊断的关键应用推进了基于光材料的传感.

关键词:

亚利法生物氨基芳香生物氨基染色体反应银河糖非共价相互作用合成

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