阿雷卡坚果和口腔膜纤维化:一个叙述性回顾
Kimia Kazemi1, Asmaa Fadl1, Felipe F Sperandio1
1College of Dentistry, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK S7N 5E4, Canada.
Dentistry journal
|August 27, 2025
概括
甲核 (AN) 会导致口腔下粘膜纤维化 (OSF),这是一种导致口腔运动受限和口腔癌风险增加的衰弱性疾病. 通过激活肌纤维细胞,AN中的阿雷科林驱动纤维化,突显出需要新的诊断和治疗点.
科学领域:
- 口腔病理学
- 纤维性疾病
- 与果相关的疾病
背景情况:
- 口腔下粘膜纤维化 (OSF) 影响约5%的甲果 (AN) 者,导致口腔纤维化的进展.
- 导致口腔开口受限,口受损,吞,发言,生活质量下降.
- 患有OSF的患者患口腔癌的风险增加了4%,这通常与和吸烟有关.
研究的目的:
- 调查导致口腔下粘膜纤维化 (OSF) 的机制.
- 确定参与OSF病变的关键分子参与者和细胞效应因子.
- 强调对OSF新型诊断标记和治疗策略的需要.
主要方法:
- 使用暴露于阿雷科林的培养纤维细胞的体外研究.
- 涉及暴露于AN提取物或阿雷科林的小鼠的体内研究.
- 亲纤维基因和蛋白质表达的分析 (TGF-β1,CCN2,α-SMA,Col1A1).
主要成果:
- 亚雷科林是一种关键的AN类化合物,在体外诱导纤维细胞分化为表达α-平滑肌肉动蛋白 (α-SMA) 的肌纤维细胞.
- 阿雷科林促进转化生长因子-β1 (TGF-β1) 和细胞通信网络因子2 (CCN2) 的表达.
- 在体内研究表明膜下原积累和肌纤维细胞分化与上调的亲纤维基因对AN或阿雷科林的反应.
结论:
- 阿雷卡坚果 (AN) 的是口腔下纤维化 (OSF) 的重要原因,由阿雷科林的纤维化特性驱动.
- 肌纤维细胞是OSF中的关键效应细胞,阿雷科林促进它们的激活和益纤维细胞介质的释放.
- 迫切需要以机制为重点的研究来开发OSF全球负担的诊断和治疗方法.
相关概念视频
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
2.2K
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
2.2K
Chronic Bowel Disorders: Introduction
948
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
948
Barrett Esophagus-II: Clinical Manifestations and Management
1.6K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.6K
Esophageal Strictures-II: Clinical Features and Management
978
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
978
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Inflammatory Bowel Disease V: Surgical Management
878
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
878


