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胆的代谢转化为三甲基氨酸主要发生在远端结肠微生物体内

Anthony M Buckley¹, Sarah Zaidan¹, Michael G Sweet²

¹Microbiome and Nutritional Science Group, Faculty of Food Science and Nutrition, School of Food Science, University of Leeds, Leeds LS2 9JT, UK.

|August 27, 2025

概括

肠道微生物将胆转化为TMA, 这是一种与心血管疾病相关的TMAO前体. 与中间和远端结肠相比,TMA的产生在近端结肠中明显较低.

科学领域:

微生物代谢
心血管疾病研究
肠道微生物组

背景情况:

肠道微生物对胆转化为三甲基胺 (TMA) 的代谢启动了三甲基胺N-氧化物 (TMAO) 的产生.
TMAO是一种循环代谢物,涉及动脉样硬化和心血管疾病 (CVD).
对结肠区域TMA产生的有限理解阻碍了减轻心血管疾病风险的策略.

研究的目的:

研究人类肠道微生物群对胆转换的区域差异.
在体外不同结肠区域中描述TMA的产生.
提供控制TMA和TMAO水平的策略,以降低心脏病风险.

主要方法:

使用一种新型的三隔间MiGut体外模型模拟近距离,中距离和远距离结肠环境.
使用同位素标记的胆基质来追踪转化为TMA.
量化了TMA的产生和分析了cutC基因的丰度.

主要成果:

在6至8小时内,胆转化为TMA在中肠和远肠 (血管2-3) 中高.
在近腹部 (血管1) 观察到胆转化为TMA的最小值.
对于TMA产生至关重要的cutC基因在靠近结肠中最为丰富,这表明其活动或活力受到抑制.

结论:

从胆中产生TMA的肠道微生物活动在结肠内表现出区域特异性.
能够产生TMA的细菌遍布整个结肠,但它们的活性因区域而异.
这些发现对了解心脏病发病和制定有针对性的干预措施来降低TMAO水平有影响.

关键词:

TMA溶解酶的使用胆肠道微生物组三甲基胺三甲基胺N-氧化物切割

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