在重症监护室的宿主微生物相互作用
Maria Adriana Neag1, Andrei Otto Mitre2, Irina Georgiana Pomana3
1Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
严重的疾病会导致肠道失调, 改变微生物平衡并影响患者的健康. 营养和向疗法在恢复肠道微生物群和改善重症患者的结果方面表现有前途.
科学领域:
- 微生物学
- 危急护理医学
- 胃肠病学
背景情况:
- 严重的疾病会严重破坏肠道微生物群,
- 这种不平衡的特点是减少多样性和增加致病细菌.
- 肠道失调会损害屏障完整性,调节免疫反应,并导致全身炎症和器官功能障碍.
研究的目的:
- 审查关键病患者肠道微生物群变化的现有证据.
- 探索这种失调的系统性后果.
- 评估营养和微生物群向治疗对患者结果的影响.
主要方法:
- 对当前证据的文献审查.
- 对关键疾病中的肠道微生物群变化的研究分析.
- 对营养和治疗干预措施的评估.
主要成果:
- 严重的疾病会引起显著的肠道失调,并减少微生物多样性.
- 肠道营养支持微生物多样性,而肠道营养则加剧了不平衡.
- 益生菌,益生菌,协生菌和发酵产品显示出恢复微生物平衡的潜力.
结论:
- 肠道功能失调是一种严重疾病的严重并发症,具有全身影响.
- 营养策略在ICU中调节肠道微生物群中起着至关重要的作用.
- 针对微生物群的疗法可以改善重症患者的治疗结果.
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