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通过火花烧结制造的多孔结构上的生物相容混合表面层

Konstantine V Nadaraia¹, Anastasia A Golysheva², Evgeniy A Belov¹

¹Institute of Chemistry FEB RAS, 159 Pr. 100-letiya Vladivostoka, Vladivostok 690022, Russia.

Journal of functional biomaterials

|August 27, 2025

概括

这项研究开发了先进的3D (Mg) 支架,采用混合涂层,以提高生物相容性. 这些新的植入材料显示出增强的湿透性和表面粗性,

科学领域:

生物材料科学
材料工程
骨科研究

背景情况:

三维 (Mg) 支架对骨再生具有前景.
提高生物相容性和机械性能对于骨科植入物至关重要.
目前的Mg支架需要进行表面修改以改善整合.

研究的目的:

开发具有混合生物活性涂层的先进3D脚架.
评估涂层对脚手架形态,湿度和表面粗性的影响.
评估这些支架作为下一代植入材料的潜力.

主要方法:

用于3D基架制造的火花等离子烧结 (SPS).
酸涂层的等离子电解氧化
混合涂层包含万科米辛,佐尔德龙酸和Menaquinone MK-7.
使用XRD,XRF,SEM,EDS和OSP进行表征;接触角度测量.

主要成果:

成功制造了含有酸的生物活性涂层的3D基架.
涂层显著改善了湿透性 (接触角度从123.8°减少到26.9°).
表面粗度增加了三倍以上,增加了细胞粘附的可能性.
架表现出具有生物活性物质的发展形态.

结论:

开发的混合涂层增强了3DMg支架的表面性能.
这些改造的支架显示出作为个性化植入物的先进生物材料的巨大潜力.
这些发现有助于开发具有改进功能特性的新骨科植入材料.

关键词:

氧化合金梅纳基MK-7 血电解氧化聚多巴胺闪电等离子烧结黄素的使用情况黄酸盐

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