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在白点损伤重矿化中的素酸 (CPP-ACP) 的作用 - 一个系统性审查

Valentina Baccolini¹, Lígia Pereira da Silva¹, Liliana Teixeira¹

¹FP-I3ID, Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal.

Journal of functional biomaterials

|August 27, 2025

概括

酸-非形酸 (CPP-ACP) 有效地重矿化白斑病变 (WSL),特别是与化物结合使用. 需要进一步的研究来证实长期临床研究中的这些发现.

科学领域:

生物材料科学
牙科研究
预防性牙科

背景情况:

无形酸盐 (ACP) 是一种有助于牙硬组织重矿化的生物陶材料.
白斑病变 (WSL) 是早期的牙去矿化阶段,常见于正牙患者或口腔卫生不良患者.
基于ACP的重矿化剂对WSL的临床有效性需要进一步研究.

研究的目的:

系统地审查素酸盐-无形酸盐 (CPP-ACP) 产品的临床疗效.
为了比较CPP-ACP与非生物陶处理的有效性.
评估CPP-ACP与化物对WSL重矿化的影响.

主要方法:

在PROSPERO注册的系统审查 (CRD42024540595).
包括随机临床试验,前性队列研究和对具有永久牙的人类受试者的试点研究.
排除人工WSL或非心脏病变的研究;使用Cochrane风险偏差2 (RoB2) 工具进行质量评估.

主要成果:

分析了14篇文章,表明CPP-ACP在重矿化WSL中的临床有效性,尽管有一些研究不一致.
与安慰剂和树脂透治疗相比,CPP- ACP的疗效更高.
将CPP-ACP与化物相结合似乎可以增强WSL的重矿效应.

结论:

在CPP-ACP的临床研究中,白斑病变的重矿化显得有前途.
在WSL治疗中,CPP-ACP可能比安慰剂和树脂透更有效.
需要进行进一步的标准化临床研究和延长的随访,以验证这些发现.

关键词:

无形酸盐生物陶材料酸-无形酸面膜重矿化白斑病变

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