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Updated: Sep 10, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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在肝细胞癌中,阿弗拉托克素诱导的p53异常与乙型肝炎病毒之间的合作

Carolina Moreno-León1, Francisco Aguayo1

  • 1Laboratorio de Oncovirología, Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad de Tarapacá, Arica 1000000, Chile.

Journal of xenobiotics
|August 27, 2025
PubMed
概括

当阿弗拉托克素暴露和乙型肝炎病毒 (HBV) 感染同时存在时,肝细胞癌 (HCC) 的风险会增加. 这两种因素都会损害p53瘤抑制路径,这是HCC发展的关键机制.

关键词:
没有HBV其他:R249S 其他发生TP53突变非洲毒素B1癌症发生肝细胞癌其他协同作用

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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