专注于生物试验的既定和新兴喘生物标志物:叙述性审查
Philip F Lavere1, Kaitlin M Phillips1, Nicola A Hanania1
1Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Journal of personalized medicine
|August 27, 2025
概括
生物标志物精确地描述了喘的内型, 新兴的生物标志物有望更有效地治疗喘和缓解喘,改善患者的治疗结果.
科学领域:
- 肺病学和过敏
- 翻译医学
背景情况:
- 喘的特征是慢性呼吸道炎症和可变的气流阻塞,由不同的分子内型驱动.
- 生物标志物对于内型特征至关重要,使得在临床试验中设计,监测和评估喘生物疗法.
研究的目的:
- 审查生物标志物在理解和治疗喘中的演变作用,重点关注已批准的生物药物和新型标志物.
- 突出生物标志物如何促进喘研究和临床实践.
主要方法:
- 在喘研究和临床试验中使用的已知和新兴生物标志物的审查.
- 专注于有助于表征2型 (T2) 喘内型的生物标志物.
- 包括生物标志物,如血清IgE,血红素,FeNO,皮质素,细胞,TARC,eotaxin-3,EPX,CC16和QCT成像.
主要成果:
- 已确定的生物标志物 (血清IgE,血红素,FeNO,质素) 阐明了T2喘内型.
- 新兴的生物标志物 (细胞,TARC,eotaxin-3,EPX,CC16,QCT) 在临床试验和专门中心中越来越多地被使用.
- 生物标志物对于评估生物疗法的有效性和了解喘病理生理学是不可或缺的.
结论:
- 生物标志物对于喘治疗的进步至关重要,
- 持续的研究和生物标志物的应用为个性化喘治疗铺平了道路.
- 最终目标是通过生物标志物导向治疗实现无症状的喘缓解.
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