在患有肺结核感染和多发性硬化症的患者中QuantiFERON- TB- Plus结果的表征
Elisa Petruccioli1, Luca Prosperini2, Serena Ruggieri2
1Translational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Neurology international
|August 27, 2025
概括
患有多发性硬化症 (MS) 和结核感染 (TBI) 的患者与单独患有TBI的患者相比,QuantiFERON- TB- Plus (QFT- Plus) 测试反应较低. 在MS-TBI组中,边界QFT-Plus结果更频繁,影响了结核病查的准确性.
科学领域:
- 免疫学
- 神经学
- 传染性疾病
背景情况:
- 多发性硬化症 (MS) 的疾病修饰药物 (DMD) 与结核病 (TB) 的风险增加有关.
- 使用QuantiFERON-TB-Plus (QFT-Plus) 测定用于查潜伏结核病感染 (LTBI).
- 对于多发性硬化症患者的QFT- Plus效果有有限的数据.
研究的目的:
- 为了比较患有TBI (MS-TBI) 的多发性硬化症患者和没有MS的多发性硬化症患者 (NON-MS-TBI) 的QFT-Plus反应.
- 记录对TB1/TB2刺激的不一致的QFT-Plus反应.
- 分析与人口因素,临床数据,DMD使用和结核病暴露史相关的QFT-Plus结果.
主要方法:
- 在2018年至2023年期间对810名多发性硬化患者进行潜在的TBI查.
- 招募20名MS-TBI患者和106名非MS-TBI对照人进行QFT-Plus测试.
- 两组之间的干扰素 (IFN-γ) 生产的比较.
主要成果:
- 与非MS- TBI患者相比,在TB1 (p=0. 01) 和TB2 (p=0. 02) 刺激后,IFN- γ的产生显著降低.
- 与非MS- TBI患者相比,更多的MS- TBI患者 (30%) 在TB2刺激的灰色区域中获得QFT- Plus结果 (7%,p=0. 002).
结论:
- 与仅患有TBI的患者相比,MS- TBI患者的QFT- Plus反应减少,边缘结果的频率更高.
- 需要进一步的研究来阐明这些边界QFT-Plus结果在MS患者中的临床意义.
- 在这一群体中澄清QFT-Plus的解释可能会提高其对MS患者结核病预测的准确性.
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