老年妇女的克隆性血液形成和心血管结果
Daniel Ezzat1, Md Mesbah Uddin2, Liying Xue2
1Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Faculty of Medicine, KU Leuven, Leuven, Belgium.
不确定潜力 (CHIP) 亚型,特别是TET2,ASXL1和JAK2的克隆造血仍然与老年妇女的心血管疾病 (CVD) 风险有关. 这些发现突出了CHIP
科学领域:
- 心血管科学
- 遗传学
- 老龄化研究
背景情况:
- 不确定潜力的克隆造血 (CHIP) 是与衰老相关的心血管疾病 (CVD) 的新兴危险因素.
- 之前的研究表明CHIP与心血管疾病的关联可能在晚年减少.
研究的目的:
- 研究CHIP及其亚型与老年女性心血管疾病的相关性.
- 确定CHIP是否仍然是老年人心血管事件的重要风险因素.
主要方法:
- 使用高覆盖度测序的妇女健康倡议长寿研究数据.
- 作为暴露的复合CHIP,TET2CHIP和其他亚型 (DNMT3A,ASXL1,JAK2).
- 使用考克斯模型评估发生的冠心病,心力衰竭 (HFpEF,HFrEF),中风,静脉血栓塞和心血管死亡.
主要成果:
- 在6677名老年女性中,有32.6%患有CHIP.
- TET2 CHIP与冠状动脉疾病 (aHR: 1.36) 和HFpEF (aHR: 1.40) 的风险增加有关.
- ASXL1 CHIP与HFrEF相关 (aHR: 3. 16),JAK2 CHIP与缺血性中风 (aHR: 2. 49),静脉血栓塞栓症 (aHR: 2.71) 和心血管死亡 (aHR: 2. 62).
结论:
- 特定的CHIP亚型 (TET2,ASXL1,JAK2) 与老年女性的心脏病发作有关.
- 这项研究表明CHIP对晚年心血管健康的持续相关性.
- 关联因特定的心血管疾病结果而异,表明有明显的病理生理联系.
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