Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

156
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
156
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

92
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
92

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Isoflurane Is Effective for Anesthesia of the Greater Wax Moth (<i>Galleria mellonella</i>) Larvae.

Insects·2026
Same author

Host immunity and recurrent <i>Clostridioides difficile</i> infection: a comprehensive review.

Pathogens and global health·2026
Same author

Pmel17 Deficiency Affects Melanogenesis and Promotes Tumor Vascularization.

International journal of molecular sciences·2026
Same author

Analysis of the Response of <i>Chlamydomonas reinhardtii</i> to Cobalt Ions Reveals the Protective Role of Thiols, Ascorbate, and Prenyllipid Antioxidants, and the Negative Impact of Cobalt Toxicity on Photoprotective Mechanisms.

Plants (Basel, Switzerland)·2025
Same author

The advantages of <i>Faecalibacterium prasnitzii</i> in gestational diabetes mellitus.

Future microbiology·2025
Same author

Photoreactive Properties of Melanin Obtained from Human Induced Pluripotent Stem Cell-Derived Melanocytes.

International journal of molecular sciences·2025

相关实验视频

Updated: Sep 10, 2025

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
09:18

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks

Published on: December 2, 2022

1.2K

基性化合物2-甲基-1,4-纳夫托金在体外和体内对病原性Prototheca物种具有广泛的有效性

Amir Aliramezani1, Grzegorz Szewczyk2, Krystian Mokrzyński2

  • 1Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.

Antimicrobial agents and chemotherapy
|August 27, 2025
PubMed
概括
此摘要是机器生成的。

一种新型化合物2-甲基-1,4-纳夫托金对新出现的病原体Prototheca具有很高的活性. 这种纳夫托基衍生物有效治疗Prototheca感染,并为新药开发提供了有希望的线索.

关键词:
二甲基-1,4-纳夫托基原始书其他其他疾病抗菌药物生物膜鼠标模型纳夫托基诺

更多相关视频

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

6.6K
Development of Metarhizium anisopliae as a Mycoinsecticide: From Isolation to Field Performance
14:15

Development of Metarhizium anisopliae as a Mycoinsecticide: From Isolation to Field Performance

Published on: July 30, 2017

20.9K

相关实验视频

Last Updated: Sep 10, 2025

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
09:18

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks

Published on: December 2, 2022

1.2K
Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
06:47

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

6.6K
Development of Metarhizium anisopliae as a Mycoinsecticide: From Isolation to Field Performance
14:15

Development of Metarhizium anisopliae as a Mycoinsecticide: From Isolation to Field Performance

Published on: July 30, 2017

20.9K

科学领域:

  • 微生物学
  • 菌群学
  • 药物发现

背景情况:

  • 在人类和动物中引起难以治疗的感染的新兴病原体.
  • 现有的抗真菌和抗菌疗法在很大程度上对Prototheca无效,因为它具有独特的生物学特性.

研究的目的:

  • 识别和描述对Prototheca有效的新疗法.
  • 探索植物和藻类等位基化合物作为抗Prototheca剂的潜力.

主要方法:

  • 对抗Prototheca活性进行选.
  • 在体外对各种Prototheca分离物 (浮游生物和生物膜) 进行测试.
  • 使用Prototheca bovis皮肤感染的小鼠模型进行体内疗效测试.

主要成果:

  • 在实验室中,2- methoxy-1,4- naphthoquinone对各种Prototheca物种表现出强烈的活性.
  • 该化合物诱导了反应性氧物种和向线粒体能量生产.
  • 在小鼠模型中成功治疗了Prototheca bovis的皮肤感染.

结论:

  • 这是一种新且有效的抗Prototheca化合物.
  • 1,4-纳夫托金支架代表了开发新疗法治疗Prototheca感染的有希望的线索.
  • 基化合物是发现新型抗Prototheca疗法的可行来源.