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利用病毒特异性T细胞:在不同人群中扩大治疗策略

Navid Djassemi¹, Benjamin Hanisch², Cecilia Motta²

¹Children's National Medical Center, Dana Point, California, United States.

|August 27, 2025

概括

病毒特异性T细胞 (VSTs) 在移植后对免疫功能低下的患者提供有效的病毒控制. 这篇评论详细介绍了VST的制造,安全性,有效性以及对CMV和COVID-19等感染的扩展应用.

科学领域:

免疫学
细胞治疗
病毒学

背景情况:

病毒特异性T细胞 (VST) 的采用转移是治疗免疫功能低下个体病毒感染的有希望的策略.
接受血造干细胞移植 (HCT) 和固体器官移植 (SOT) 的患者特别容易感染细胞大脑病毒 (CMV),爱斯坦-巴尔病毒 (EBV),腺病毒 (Adv) 和BK病毒等病毒性疾病.

研究的目的:

审查VST用于治疗病毒感染的制造工艺,可行性,安全性和有效性.
突出最近的视觉仪表制造进步及其对可访问性的影响.
讨论安全问题和探索新兴的VST应用.

主要方法:

对临床实践和研究中VST的现有文献的审查.
对实例研究进行分析,以证明VST的实际应用.
检查制造技术,安全性 (包括细胞因子释放综合征 (CRS) 和移植对宿主疾病 (GVHD)) 和疗效数据.

主要成果:

临床试验表明VST可以有效控制CMV,EBV,Adv和BK病毒.
VST 提供了传统抗病毒疗法的替代方案,其毒性降低.
制造业的进步正在为更广泛的应用增加VST的可用性.

结论:

在免疫功能低下的患者中,VST是一种安全有效的治疗选择.
目前正在研究将VST应用扩展到新的病毒目标,包括COVID-19.
解决实施障碍对于更广泛的临床采用VST至关重要.

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