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Updated: Sep 10, 2025

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Published on: September 20, 2024

恢复视网酸:减轻Sox5缺乏的小鼠的自闭症行为

Lanyan Lin¹, Yongxing Lai¹, Ainong Mei¹

¹Department of Geriatric Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Key Laboratory of Geriatric Diseases, Fujian Provincial Center for Geriatrics, Fuzhou University Affiliated Provincial Hospital, Fuzhou University School of Medicine, Fuzhou, 350001, China.

Neuroscience bulletin

|August 27, 2025

概括

No abstract available in PubMed .

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Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...