在SARS-CoV-2引起的孕产妇免疫激活后,人类神经发育早期的性别特异性脆弱性
Alexandre Díaz-Pons1,2,3,4, Sergio Castaño-Castaño5,6,7, Víctor Ortiz-García de la Foz1
1Departamento de Investigación en Enfermedades Mentales, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, 39011, España.
European child & adolescent psychiatry
|August 27, 2025
概括
孕妇在怀孕期间感染SARS-CoV-2可能会根据性别不同影响婴儿的神经发育. 与男性相比,女性婴儿的定向和调节能力有所下降,这表明母亲免疫激活的性别特异性脆弱性.
科学领域:
- 神经科学
- 发展心理学
- 免疫学
背景情况:
- 由SARS-CoV-2感染引起的孕产妇免疫激活 (MIA) 是对胎儿发育的关注.
- 早期神经发育结果和性别特异性脆弱性需要进一步调查.
研究的目的:
- 检查SARS-CoV-2引起的MIA对婴儿神经发育的性别特异性影响.
- 评估在子宫内暴露于母体SARS-CoV-2感染的婴儿的行为和调节功能.
主要方法:
- 来自COGESTCOV-19研究的107个母婴二合体的分析.
- 使用新生儿行为评估尺度 (NBAS) 进行神经发育评估.
- 测量母亲和新生儿的细胞因子水平 (IL-6,IL-10,IL-6/IL-10比率).
主要成果:
- 病例和对照对母体或新生儿细胞因子水平没有显著差异.
- 在神经发育结果中观察到显著的性别差异.
- 与暴露的男性和未暴露的婴儿相比,在子宫中暴露的女性婴儿的方向和状态调节有所减少.
结论:
- 根据婴儿的性别,SARS-CoV-2诱导的MIA可能会对早期神经发育产生差异性影响.
- 这些发现突出了超出细胞因子平衡的潜在性别特异性脆弱性.
- 针对性干预可能是必要的,以解决这些观察到的性别特异性影响.
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