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在内动脉瘤中对低密度脂蛋白的运输及其与壁增强的关联的数值研究

Yuqing Tian^1,2, Jianjian Zhang³, Huilin Zhao³

¹Department of Engineering Mechanics, School of Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Biomechanics and modeling in mechanobiology

|August 27, 2025

概括

这项研究引入了一种新的低密度脂蛋白 (LDL) 传输在内动脉瘤 (IAs) 的模拟方法. 它揭示了在IA壁中增加的LDL沉积和积累与壁增强相关,这表明质量传输是风险评估的关键.

科学领域:

生物医学工程
计算流体动力学
血管生物学

背景情况:

血管壁成像经常检测不稳定或破裂的内动脉瘤 (IAs) 的增强.
这表明血液中的物质运输,特别是低密度脂蛋白 (LDL),可能在IA的发病过程中起作用.
了解这些传输机制对于评估IA风险和进展至关重要.

研究的目的:

开发和验证一种用于模拟IA中的LDL传输的新计算方法.
在IA中调查LDL沉积,积累和血管壁增强之间的关系.
将质量传输参数与一般血液动力学因子 (WSS,OSI) 的预测值进行比较.

主要方法:

开发了一种对联模拟模型,用于LDL传输在流体中,穿过内皮和血管壁.
纳入了一个将内皮透度与壁切削应力 (WSS) 大小和振荡切削指数 (OSI) 的子模型.
进行了4名确诊壁增强状态的患者的IA数值模拟.

主要成果:

模拟显示,与正常动脉相比,内脏动脉的LDL沉积和积累显著增加.
高LDL度的空间分布有所不同,表明区域生物力学对运输的影响.
与没有增强壁的IA相比,LDL度的区域更大.

结论:

在IA壁中增加的LDL沉积和积累与壁增强密切相关.
大众运输现象,特别是LDL行为,比WSS和OSI等一般血液动力学因素更能表明IA的病态状态.
这种方法有可能改善内动脉瘤的风险分层和分类.

关键词:

动脉瘤壁增强脑内动脉瘤低密度脂蛋白跨境运输

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