具有不同表面电荷的尼载荷颗粒的抗菌效率的评估
Rūta Gruškienė1, Alisa Gricajeva2, Jolanta Sereikaitė3
1Department of Chemistry and Bioengineering, Vilnius Gediminas Technical University, Sauletekio Al. 11, Vilnius, 10223, Lithuania.
Probiotics and antimicrobial proteins
|August 27, 2025
概括
含有尼的颗粒的表面电荷不会显著影响它们对黄金葡萄球菌和白斑菌的抗菌活性. 这一发现为设计用于食品保存的新尼输送系统提供了灵活性.
科学领域:
- 食品科学
- 微生物学
- 材料科学
背景情况:
- 尼辛是一种细菌素, 对于保存食物至关重要.
- 封装增强了尼的稳定性和与食物的相互作用.
- 粒子表面电荷对尼抗菌活性的影响需要进一步研究.
研究的目的:
- 研究尼载荷粒子表面电荷对抗菌活性的影响.
- 评估尼载荷的颗粒与金黄色葡萄球菌和杆菌.
主要方法:
- 使用素制备和涂上基托醇糖的尼载荷颗粒.
- 在不同的pH值下分析了nisin释放动力学.
- 在Gram阳性细菌菌株上评估了抗菌活性.
- 测定了粒子表面电荷的泽塔电位.
主要成果:
- 尼辛的释放遵循了科尔斯迈耶-佩帕斯模型.
- 粒子表现出负和正的表面电荷, 取决于涂层.
- 在相反充电的颗粒之间没有观察到抗菌活性的显著差异.
- 含有尼辛的颗粒对黄金菌和白菌有抗菌作用.
结论:
- 颗粒表面电荷不会严重影响尼的抗菌效果.
- 这项研究扩大了尼的配方和输送系统设计的选项.
- 这些发现支持开发基于尼的多功能抗菌剂.
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