相关实验视频
Updated: Sep 10, 2025

05:16
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
6.7K
在美国接受腹部外科手术的个体中使用类似葡萄糖的抗原剂
Minji Kim1,2, Michael A Schweitzer3, Ji Soo Kim4,5
1Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
JAMA surgery
|August 27, 2025
概括
大约14%的美国成年人在减肥手术后开始使用类似葡萄糖-1受体激活剂 (GLP-1s) 是女性,接受了袖子胃切除术或患有2型糖尿病. 更高的手术后BMI也预测了GLP-1的使用.
科学领域:
- 代谢手术
- 药物治疗
- 肥胖药物
背景情况:
- 葡萄糖类-1受体激活剂 (GLP-1s) 是有效的体重管理后腹部外科手术.
- 然而,关于GLP-1在该群体中的使用频率和预测因素的数据有限.
研究的目的:
- 在腹部手术后,对美国成年人的GLP-1启动模式进行鉴定.
- 为了确定与GLP-1相关的社会人口和临床因素,手术后使用.
主要方法:
- 使用国家电子病历数据库 (大约2年) 进行回顾性队列研究. 美国有1.13亿成年人.
- 包括在2015年1月至2023年5月期间没有先前使用GLP-1进行腹部手术的成年人.
- 考克斯的比例危险模型分析了GLP-1启动的预测因素,包括基线特征和时间依赖的术后BMI.
主要成果:
- 在112,858名患者中,有14. 0%的患者在腹部外科手术后开始使用GLP-1.
- 在女性 (aHR,1. 61),袖子胃切除术患者 (aHR,1. 42) 和2型糖尿病患者 (aHR,1. 34) 中更常见.
- 术后BMI每增加1个单位,与GLP-1启动的可能性增加了8% (aHR,1. 08).
结论:
- 在美国,每10名接受减肥手术的成年人中,大约有1人产生GLP-1.
- 与更高的GLP-1启动相关的因素包括女性性别,袖子胃切除术和更高的BMI恢复.
- 这些发现突出了患者的特征和体重的恢复,作为减肥手术后药物治疗的关键预测因素.
相关概念视频
Glucagon-like Receptor Agonists
416
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
416
Hypoglycemia and Glucagon
334
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
334
Oral Hypoglycemic Agents: Glinides
256
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
256
Oral Hypoglycemic Agents: Biguanides and Glitazones
288
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
288
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
255
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
255
Dipeptidyl Peptidase 4 Inhibitors
252
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
252

