定义人类温度调节极限:使用健康年轻人的预测模型的批判性评估
Faming Wang1,2, Huijuan Xu3, Tze-Huan Lei2
1One Health Research Group, School of Environmental Science and Engineering, Tianjin University, 300072, Tianjin, China.
概括
目前用于评估热应激的方法,如核心温度转折点 (CTIP) 和生物物理模型,在长时间暴露在热中时高估了人类的温度调节极限. 这些模型需要精确的热风险评估.
科学领域:
- 人类生理学
- 环境健康
- 温度调节研究
背景情况:
- 核心温度转折点 (CTIP) 方法和生物物理建模是评估人类温度调节极限的标准工具.
- 然而,它们在长时间暴露在热下的准确性尚未得到严格验证,这引发了对预测热应变的可靠性的担忧.
研究的目的:
- 评估CTIP和生物物理模型在长时间室内暴露的预测准确性.
- 确定当前的模型是否准确地预测受控环境条件下的人类温度调节极限和热风险.
主要方法:
- 三十六名健康成年人 (20名男性,16名女性) 在不同温度和相对湿度下进行了五次8小时的热试验.
- 参与者在穿着标准服装时执行静坐任务,并持续监测直肠温度 (Trec).
- 环境条件是基于人类温度调节极限的先前模型预测.
主要成果:
- 所有测试的热条件都是可补偿的,直肠温度上升率低于0.1°C/h,高峰温度低于热中风值.
- 与模型预测相反,人类的温度调节极限没有达到,这表明模型大大低估了耐受性.
- 虽然女性在44°C/29. 2%RH时呈现较低的Trec,但在其他条件下没有观察到稳定状态反应的显著性别差异.
结论:
- CTIP和生物物理模型显著低估了人类的温度调节极限,并高估了热风险.
- 目前的预测方法需要大量改进,以准确评估人类对长时间暴露的耐受性.
- 这些发现对于改善热风险评估和在气候变暖中为公共卫生准则提供信息至关重要.
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