通过纳米泡激活的聚焦超声波向大脑输送精确的抗体可缓解抑郁症
Wenjing Li1, Yifan Feng2, Zhouyang Xu1
1Translational Research in Ultrasound Theranostics Laboratory, School of Biomedical Engineering, ShanghaiTech University, Shanghai 201210, China.
概括
使用纳米泡的聚焦超声波 (FUS) 精确地打开血脑屏障 (BBB) 进行向药物输送. 这种方法安全地产生抗体来治疗小鼠的抑郁症症状.
科学领域:
- 神经科学
- 生物医学工程
- 药理学
背景情况:
- 由于大脑的复杂性,
- 对于大脑治疗而言,
研究的目的:
- 开发一种精确的非侵入性方法,
- 用纳米气泡对血脑屏障 (BBB) 开放的聚焦超声波 (FUS) 的疗效和安全性进行评估.
主要方法:
- 使用聚焦超声波 (FUS) 与纳米泡相结合,诱导局部和可逆的BBB开放.
- 在小鼠模型中,向侧面的 habenula 施用人类衍生的抗N-甲基-D-阿斯巴酸受体单克隆抗体 (HuMAbs).
- 评估了输送精度,抗体保留,治疗疗效和安全性 (红细胞扩散).
主要成果:
- 与微气泡相比,FUS纳米泡在BBB打开时获得了四倍的精度.
- 在脑膜中保留至少10天的HuMAbs.
- 在小鼠中,类似抑郁症的症状显著减轻 (P < 0. 01/ 0. 05).
- 最小的红细胞扩散 (0. 9 ) 表明了良好的安全性.
结论:
- FUS与纳米泡相结合, 提供了一种准确而安全的方法,
- 这种方法显示出抗体治疗和临床转换的巨大潜力,特别是在神经和精神疾病方面.
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