重组核桃衍生的可改善d-银引起的认知缺陷
Caiyun Li1,2, Dingwei Zheng1,2, Tianle Zhang1,2
1National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, China.
Journal of agricultural and food chemistry
|August 27, 2025
概括
通过调节肠道微生物群和减少神经炎症,复合核桃衍生 (rWDP) 改善了老年小鼠的认知功能. 这种可以通过肠-大脑轴治疗与年龄相关的认知衰退.
科学领域:
- 神经科学
- 微生物学
- 免疫学
背景情况:
- 衰老和神经炎症与肠道失调和通过肠-大脑轴系统性炎症有关.
- 生物活性,如核桃衍生EV-10, 显示神经退行性疾病的治疗潜力.
- 再组合核桃衍生 (rWDP) 的治疗效果需要进一步描述.
研究的目的:
- 在老化小鼠模型中研究rWDP的治疗潜力.
- 阐明rWDP对认知功能,肠道微生物群和神经炎症的影响的机制.
主要方法:
- 使用莫里斯水迷宫对d-galactose诱导老化的小鼠进行行为评估.
- 对肠道微生物组成和结肠粘膜完整性的分析.
- 测量全身炎症标志物 (IFN-γ,VCAM-1,G-CSF,CXCL1) 的情况.
- 评估大脑组织中的微质激活和神经元结构.
- 使用LPS刺激的BV2微质细胞进行了体外研究.
- 对大脑组织的代谢分析.
主要成果:
- 在老年小鼠中显著改善了空间学习和记忆.
- rWDP治疗改变了肠道微生物群,增加了Akkermansia muciniphila,改善了结肠粘膜的完整性.
- 系统性炎症减弱,IFN-γ和VCAM-1减少,G-CSF和CXCL1正常化.
- rWDP 减少了微质激活,并保留了海马神经元结构,大脑中的 p21 表达减少.
- 在体外,rWDP抑制了LPS诱导的氧化和微质细胞中的促炎基因表达.
- 代谢分析显示神经递质恒温的恢复.
结论:
- 在老年小鼠中,rWDP可通过肠脑轴和免疫调节来缓解认知缺陷.
- rWDP的作用包括肠道微生物群的有益变化和神经炎症的减少.
- 需要进一步研究以充分阐明rWDP行动的多方面的机制.
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