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在药片注射后解脱溶酶度的损失

Katharina Tatjana Kopp1, Maarten De Beer2, Jody Voorspoels2

  • 1Eurofins Amatsigroup, Industriepark-Zwijnaarde 7B, Gent 9052, Belgium; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49, Leuven 3000, Belgium.

Journal of pharmaceutical and biomedical analysis
|August 27, 2025
PubMed
概括

蛋白质的稳定性对于治疗效果至关重要. 这项研究发现,小片剂发育过程中的蛋白质损失是由于辅助剂的相互作用,而不是小片剂本身. 优化缓冲系统可以减轻这些相互作用,改善蛋白质恢复.

关键词:
分析样本的准备染色学莱索微型药片蛋白质与辅助剂的相互作用喷雾干燥

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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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