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揭示隐藏的:在土耳其废水中分析36种精神活性物质的方法验证

Merve Kuloglu Genc¹, Selda Mercan¹, Lubertus Bijlsma²

¹Istanbul University- Cerrahpaşa, Institute of Forensic Sciences and Legal Medicine, Department of Science, Buyukcekmece, 34500 Istanbul, Türkiye.

Journal of chromatography. A

|August 27, 2025

概括

废水流行病学现在监测36种精神活性药物,包括新合成阿片类药物和非法物质. 这种经过验证的方法为土耳其的毒品使用模式提供了关键的见解.

科学领域:

环境化学
法医毒理学
公共卫生

背景情况:

基于废水的流行病学 (WBE) 对于监测精神活性物质使用至关重要.
随着药物市场的发展,需要同时分析非法药物和新型精神活性物质 (NPS).

研究的目的:

开发和验证一种在废水中同时检测36种精神药物 (30种NPS,6种非法药物).
通过验证的WBE方法评估这些物质在土耳其的流行程度.

主要方法:

开发了一种新的同时固相提取 (SPE) 程序.
使用液体染色体-双重质谱法 (LC-MS/MS) 进行定性和定量测定.
该方法经过了全面的验证,包括线性,精度,稳定性,过损失,矩阵效应和分析物稳定性评估.

主要成果:

该验证的方法成功地在土耳其的63个污水样本中识别和量化了36种精神活性药物.
胺 (87%) 和ADB- BUTINACA (57%) 的检测频率较高.
检测到多种NPS,包括4F-MDMB-BUTICA和4F-MDMB-BINACA-N-4-hydroxybutyl,这标志着这些化合物在土耳其的首次WBE验证.

结论:

这项研究为土耳其广泛的NPS和非法药物的同时分析提供了第一个经过验证的WBE方法.
这些发现提供了有关该国NPS消费模式的关键基线数据.
开发的方法对于为公共卫生战略提供信息和打击非法毒品市场至关重要.

关键词:

滥用药物液体染色学-双重质谱学固体阶段提取稳定性合成大麻素

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