在口腔皮细胞癌中探索TROP2表达:与预后和瘤免疫微环境组成的关联
Juliana Mota Siqueira1, Daniele Heguedusch1, Mateus Trinconi Cunha2
1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA; Department of Stomatology, Discipline of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.
在口腔皮细胞癌 (OPSCC) 中,高Trophoblast细胞表面抗原2 (TROP2) 表达与更好的结果相关. 这一发现表明TROP2可能是一个有价值的预后标志物和潜在的治疗点.
科学领域:
- 癌症学
- 免疫学
- 生物标志物研究
背景情况:
- 口腔皮细胞癌 (OPSCC) 带来了重大的预后和治疗挑战.
- 热囊细胞表面抗原2 (TROP2) 是一种跨膜糖蛋白,涉及瘤信号,并作为各种固体瘤的治疗点进行了研究.
研究的目的:
- 在OPSCC中确定TROP2表达的流行率和预后值.
- 在OPSCC中研究TROP2表达与瘤免疫微环境 (TME) 组成之间的关联.
主要方法:
- 对112名OPSCC患者进行了回顾性分析.
- 免疫组织化学评估TROP2表达 (归类为负/低或中等/高).
- 免疫微环境相关性和生存分析的转录组分析 (Kaplan-Meier,Cox回归).
主要成果:
- 在42%的患者中发现了中等/ 高TROP2表达,与吸烟/ 酒精使用减少,周围神经侵袭减少和阳性淋巴结数量减少有关.
- 患有中度/ 高TROP2的患者的整体存活率 (OS) 和无病存活率 (DFS) 显著改善.
- 通过TCGA验证,高TROP2基因表达与显著改善的生存状况有关. 转录组数据显示TROP2高的瘤中免疫细胞数量较高.
结论:
- 在OPSCC中,高TROP2表达与有利的病理特征和改善患者存活率 (DFS和OS) 相联系.
- TROP2表达与瘤微环境中的更强大的细胞毒性免疫透物相关.
- TROP2 是一个有前途的预后生物标志物,也是OPSCC的潜在治疗点.
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