在约旦从零售生肉中分离出的Campylobacter jejuni的抗菌耐药性
Amal Mayyas1, Hamzah M Al-Qadiri2, Murad A Al-Holy3
1Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba 11821, Jordan.
Poultry science
|August 27, 2025
概括
在约旦中发现了高水平的Campylobacter jejuni,显示出显著的抗菌耐药性 (AMR). 这突显了改善卫生和抗菌药物使用管理的迫切需要,以保护公共健康.
科学领域:
- 通过食物传播的病原体
- 抗菌药物耐药性
- 分子流行病学
背景情况:
- 由Campylobacter jejuni引起的坎皮洛巴菌病是主要的食物传播疾病.
- 食品传染病原体的抗菌耐药性 (AMR) 构成了严重的公共卫生威胁.
- 肉是坎皮洛巴克特传播的常见媒介.
研究的目的:
- 确定约旦生中C. jejuni的流行情况.
- 分析C. jejuni分离物的抗菌耐药性 (AMR) 概况和耐药性基因.
- 评估 AMR 对食品传染的坎皮洛巴克的公共卫生影响.
主要方法:
- 在约旦屠宰场和零售市场采集700个生样本.
- 使用针对hipO基因的PCR检测和鉴定C. jejuni.
- 对各种抗生素进行抗菌敏感性测试 (AST).
- 通过PCR识别特定的AMR基因 (blaOXA-61,blaOXA-184,tet(O,gyrA).
主要成果:
- 在16.9%的样本中发现了C. jejuni,在零售肉中发现的较高 (19.5%).
- 观察到高耐药率的塞夫塔齐 (84. 7%),西普罗素 (72. 9%) 和四环素 (69. 5%).
- 在36. 4%的分离物体中发现了多药性耐药性 (MDR),与特定的耐药性基因相关.
结论:
- 这项研究显示,约旦肉中存在C. jejuni的严重流行,具有令人担忧的抗菌性.
- 关键的AMR基因存在,特别是在MDR分离物中,强调了耐药性的遗传基础.
- 紧急干预,包括抗菌管理,加强卫生和监测,对于减轻公共卫生风险至关重要.
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