在心脏导管患者中加速转录的年龄和与交通有关的空气污染的敏感性
Thomas W Jackson1, Lydia Coulter Kwee2, Svati H Shah2
1Center for Public Health and Environmental Assessment, US EPA, Chapel Hill, NC 27514, United States of America.
The Science of the total environment
|August 27, 2025
概括
加快的转录和表观遗传年龄表明对与交通有关的空气污染 (TRAP) 的敏感性增加. 这两种加速衰老的个体面临着TRAP暴露带来的更大的环境健康风险.
科学领域:
- 环境健康
- 基因组学
- 生物标志物
背景情况:
- 加快的转录和表观遗传年龄是系统性健康干扰和环境暴露敏感性的建议生物标志物.
- 之前的研究发现表观遗传年龄加速是城市人口与交通相关的空气污染 (TRAP) 敏感性的生物标志物.
研究的目的:
- 调查与TRAP相关的心血管风险是否因转录组衰老而发生变化.
- 评估转录和表观遗传加速对TRAP相关心血管结果的综合影响.
主要方法:
- 使用了1024名CATHGEN队列参与者的数据.
- 评估TRAP使用住宅靠近主要道路;结果包括外围动脉疾病 (PAD) 和血压.
- 使用基于血液的基因表达 (GEXAge AAD) 和Horvath表观遗传年龄 (DNAmAge AAD) 测量年龄加速,调整为共变量.
主要成果:
- 在TRAP和GEXAge AAD和DNAmAge AAD之间发现了显著的相互作用,特别是在城市环境中.
- 加快的转录或表观遗传年龄增强了道路近距离与PAD之间的联系.
- 在表观遗传和转录基因年龄加快的个体中观察到最强的相互作用.
结论:
- 与表观遗传年龄相似的转录基因年龄可能表明TRAP敏感性增加.
- 同时表观遗传和转录组年龄较高的个体可能面临更高的环境健康风险,而不是仅仅转录组年龄较高的个体.
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