在精神分裂症患者的alexithymia中,异常的前部岛屿是感觉缺陷的基础
Haoran Shen1, Yaping He2, Renjie Zeng2
1State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, Beijing, China.
精神分裂症患者表现出脑海内脑部活动的变化, 这突出了前面的岛屿在整合身体的感觉和情绪的作用.
科学领域:
- 神经科学
- 精神病学
- 认知科学
背景情况:
- 精神分裂症通常与自我意识和情绪处理的改变有关.
- 亚历克西西米亚的特点是难以识别和表达情绪,经常与精神分裂症同时发生.
- 感知内在的身体状态对于情绪调节至关重要, 在精神疾病中常常受到损害.
研究的目的:
- 在精神分裂症患者中研究异常整体感应的神经机制.
- 识别脑皮层中的异常激活和功能连接模式及其与情绪处理区域的连接.
主要方法:
- 评估了50名精神分裂症患者的亚历克西西米亚 (多伦多亚历克西西米亚尺度) 和整体意识 (多维整体意识评估).
- 基于任务的功能磁共振成像 (fMRI) 用于检查脑部活动.
主要成果:
- 与没有alexithymic患者相比,alexithymic精神分裂症患者在interoceptive任务中表现出较低的前部insula (AI) 激活.
- 在alexithymic患者中,观察到AI与前带皮层 (ACC) 和上额头环 (SFG) 之间的功能连接减少.
- 在AI-ACC连接中介于整体感受和alexithymia之间的关系.
结论:
- 精神分裂症患者难以将感知信号与情感突出结合起来.
- 在这种患者群体中,前半岛在整体感知意识和情感表达之间的相互作用中起着关键作用.
- 研究结果表明,在亚历克西性精神分裂症中,有潜在的神经生物学途径进行针对性干预.
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