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Updated: Sep 10, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
11:27

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050

Published on: May 13, 2020

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通过小分子激活TMEM175的结构洞察

Xuewu Zhu1, Meixuan Ping2, Heng Liu3

  • 1Zhongshan Institute for Drug Discovery, SIMM, Zhongshan 528400, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Neuron
|August 27, 2025
PubMed
概括

通过清除有毒的α-synuclein,可以治疗帕金森病 (PD). 这项研究揭示了TMEM175的开放结构与新型激动剂,为新的PD疗法铺平了道路.

关键词:
帕金森病这是一个很好的机会.抗生素绑定位置溶酶体

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