深入了解旋转片机内部结构与壁压力波动之间的关系
Yusuke Imayoshi1, Keigo Hanyu2, Shuji Ohsaki1
1Department of Chemical Engineering, Osaka Metropolitan University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
International journal of pharmaceutics
|August 27, 2025
概括
剩余的压力与药片封装有关. 这项研究使用了X射线计算机断层扫描和压力监测,以显示内部平板电脑裂如何影响压力波动,从而可能预测平板电脑的缺陷.
科学领域:
- 制药科学
- 材料科学
- 机械工程
背景情况:
- 作为一种常见的缺陷,片的封闭通常与片喷射后的剩余壁压有关.
- 了解板块内部结构与模板壁压力之间的关系对于防止封顶缺陷至关重要.
研究的目的:
- 研究药物片的内部结构与在片时的压力之间的相关性.
- 分析内部裂的形成和分布如何影响压力波动.
主要方法:
- 在片制过程中实时监测压力.
- 进行X射线计算机断层扫描 (X射线CT) 图像检测,以分析板块内部结构和裂形成.
- 压力数据与内部裂分布之间的相关性分析.
主要成果:
- 观察到两个不同的剩余压力行为:在较低的压缩力 (15 kN) 时突然下降,在较高的压力 (20 kN) 时暂时增加.
- 乙氨基颗粒乳糖混合物表现出不同的压力概况,而单纯乳糖片则在高强度时呈现出一致的增加.
- 内部裂位置 (上边与两边) 与特定的压力下降或短暂的增加相关,并且应变仪位置反映了裂分布.
结论:
- 内部裂分布显著影响药片使用期间的壁压波动.
- 在旋转片剂机中测量压力可以预测药品片的内部结构和缺陷.
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