患有阿片类药物使用障碍的退伍军人住院后与死亡相关的因素
Michael A Incze1, Sophia Huebler2, Jacob D Baylis3
1Division of General Internal Medicine, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA; Program of Addiction Research, Clinical Care, Knowledge, and Advocacy (PARCKA), Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
住院增加了阿片类药物使用障碍患者的死亡风险. 长时间停留等因素会增加死亡风险,而无家可归和布普伦诺芬治疗可能会降低死亡风险,指导未来的OUD治疗策略.
科学领域:
- 临床医学
- 公共卫生
- 上 精神病学
背景情况:
- 患有阿片类药物使用障碍 (OUD) 的患者经常住院.
- 虽然这些活动提供了参与的机会,但它们也带来了不稳定性,并与退院后的死亡率增加有关.
- 识别风险因素对于改善过渡期护理至关重要.
研究的目的:
- 在OUD的退伍军人中检查与医疗住院后死亡相关的患者级因素.
- 区分与阿片类药物相关死亡率相关的因素.
- 为开发风险分层工具和量身定制的干预提供信息.
主要方法:
- 退伍军人卫生管理局 (VHA) 的回顾性队列研究.
- 包括至少一次住院治疗的OUD退伍军人 (2011-2021年).
- 分析了住院后30天和365天间临床/人口因素与死亡率之间的关联.
主要成果:
- 年龄较大,医疗复杂性较高,多种物质使用障碍 (SUD) 和住院时间较长与全因死亡率的增加有关.
- 无家可归,抑郁症,双相情感障碍,布普伦诺芬接收和服务连接与全因死亡率的降低有关.
- 年龄较小,无家可归和多种SUD与阿片类药物相关的死亡率增加有关,而黑人种族和服务联系与阿片类药物相关的死亡率降低有关.
结论:
- 在OUD的退伍军人中,患者层面的因素显著影响住院后的死亡风险.
- 住院时间和并发症等因素影响全因死亡率,而特定的人口结构和治疗方式则影响与阿片类药物相关的死亡率.
- 这些发现有助于制定针对性的干预措施和风险分层工具,以加强过渡期护理.
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