血红蛋白糖化指数与患有出血性中风的重症患者的全因死亡率之间的关联:多中心回顾性研究
Ningyu Wei1, Yuhang Peng1, Haipeng Chen1
1Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Rd, Yuzhong, Chongqing, 400010, China.
World neurosurgery
|August 27, 2025
概括
较高的血红蛋白糖化指数 (HGI) 与出血性中风患者的死亡率较低有关. 这一发现表明HGI可以成为HS病例风险监测和分层的有用工具.
科学领域:
- 神经学
- 内分泌学
- 危急护理医学
背景情况:
- 血流性中风是全球死亡和残疾的主要原因.
- 血红蛋白糖化指数 (HGI) 与各种疾病的不良结果有关.
- 在HS患者中HGI的预后值尚不清楚.
研究的目的:
- 在重症HS患者中研究HGI与全因死亡率 (ACM) 之间的关联.
- 评估HGI对HS死亡风险分层的预后意义.
主要方法:
- 使用MIMIC- IV数据库对1664名HS患者进行研究.
- 使用糖化血红蛋白 (HbA1c) 和空腹血葡萄糖 (FPG) 计算HGI.
- 使用Cox比例危险模型,限制立方线 (RCS) 和子组分析.
主要成果:
- 在HS患者中发现HGI和30天ACM之间存在显著的反向关系.
- 与低HGI组 (T1) 相比,高HGI组 (T2,T3) 的死亡风险显著降低.
- RCS 显示出非线性关联,子组分析表明年龄与 ACM 的 HGI 相互作用.
结论:
- 在HS患者中,高HGI与全因死亡率的显著降低有关.
- HGI显示出作为HS有价值的监测指数的潜力.
- 在出血性中风中,HGI可以作为一种有效的风险分层工具.
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