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Updated: May 10, 2026

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新型 WRN 抑制剂的高通量评估

Haiyan Xu1, Rachel L Palte2, Meredith M Rickard2

  • 1Dept of Quantitative Biosciences, Merck Research Laboratories Discovery, Preclinical and Translational Medicine, Merck & Co. Inc., Rahway, NJ, USA.

SLAS discovery : advancing life sciences R & D
|August 27, 2025
PubMed
概括

针对维纳综合征化酶 (WRN) 为治疗微卫星不稳定性 (MSI-H) 癌症提供了一种新的策略. 通过利用它们的DNA修复漏洞,抑制WRN可以选择性地杀死MSI-H瘤细胞,从而为新的癌症治疗铺平道路.

关键词:
生物化学基于细胞的测试癌症学药理学进行查小分子药物发现结构导向药物设计WRN螺旋酶

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