自然史结果中度三角吐与保存的左心室喷射分数
Davide Margonato1, Michele Morosato2, Giacomo Ingallina2
1Cardiovascular Imaging Unit, Cardiothoracic Department, IRCCS San Raffaele Scientific Institute, Milan, Italy; Cardiovascular Imaging Research Center and Valve Science Center, Minneapolis Heart Institute and Foundation, Minneapolis, MN, USA.
International journal of cardiology
|August 27, 2025
概括
中度三回 (TR) 患者有保存的喷射分数面临死亡和心力衰竭住院的重大风险. 肺动脉压力较高和某些左侧门状况的结果更糟.
科学领域:
- 心脏病学
- 心脏膜疾病
- 心声检查
背景情况:
- 中度三回 (TR) 的自然病史与左心室喷射分数 (LVEF) 的保存以及没有严重的左心病 (VHD) 尚不清楚.
- 了解这一患者群体的结果对于临床治疗至关重要.
研究的目的:
- 评估被诊断为中度TR,保持LVEF且没有同时出现严重左侧VHD的患者的长期结果.
- 确定影响预后的因素,包括肺动脉静脉压 (PASP) 和同时存在的中度左侧VHD.
主要方法:
- 在2012年至2020年期间,对1198名中度TR患者进行了评估.
- 主要结果是全因死亡;次要结果是全因死亡和心力衰竭 (HF) 住院的综合结果.
- 分析中考虑了PASP和中度左侧VHD,随访时间中位数为2. 9年.
主要成果:
- 三年生存率为69%,明显低于一般人群 (p < 0. 001).
- 没有复合结果的三年生存率为63%.
- 较高的PASP与更差的预后相关. 单独的中度TR患者的年死亡率为8. 9%.
结论:
- 中度TR患者保持LVEF并且没有严重的左侧VHD面临死亡和HF住院的重大风险.
- 早期识别和管理PASP升高等因素对于改善这一群体的结果至关重要.
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