患有精神分裂症或双相情感障碍的家庭高风险儿童的性别特异性皮质大脑差异
Kathrine Skak Madsen1, William F C Baaré1, Enedino Hernandez-Torres1
1Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|August 27, 2025
概括
患有精神分裂症 (SZ) 或双极性障碍 (BP) 的家族高风险 (FHR) 的儿童表现出性别特异的脑部差异. 与对照组相比,FHR-SZ组的男性脑容量较小,而FHR-BP组的女性脑容量较大.
科学领域:
- 神经科学
- 精神病学
- 遗传学
背景情况:
- 家庭高风险 (FHR) 是精神分裂症 (SZ) 和双相情感障碍 (BP) 的最强预测因素.
- 在FHR的儿童提供了一个独特的窗口来识别早期的脆弱性大脑标记.
- 性别特定的大脑发育轨迹需要对FHR群体的性别差异进行研究.
研究的目的:
- 在FHR-SZ或FHR-BP中研究11-12岁儿童大脑形态的性别特异性.
- 为了确定潜在的SZ和BP风险的性别特异性内因型标志物.
- 强调在神经发育精神病学研究中考虑性别的重要性.
主要方法:
- 包括278名儿童:101名FHR-SZ,64名FHR-BP和113名基于人口的对照组 (PBC).
- 在3T扫描仪上获得结构MRI扫描.
- 使用FreeSurfer提取大脑体积,皮质体积,表面积和皮质厚度.
主要成果:
- 在大脑,皮质和内体积和表面积方面发现了显著的群体性相互作用.
- 与PBC男性相比,FHR-SZ男性的脑,皮层和内体积和表面积较小.
- 在FHR-BP的女性表现出比PBC女性大脑和皮质体积.
结论:
- 在FHR-SZ和FHR-BP的儿童表现出性别特异的形态学大脑差异.
- 这些差异可能代表性别特异性的内类风险标志物.
- 未来需要进行纵向研究来追踪神经解剖学变化及其预测价值.
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