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在模拟的胃肠道环境中使用基于pectin的pH敏感水凝释放纳普洛克森药物

Parisa Hoshyarmanesh¹, Abbas Rahmati¹

¹Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran.

International journal of biological macromolecules

|August 27, 2025

概括

这项研究开发了一种基于pectin的水凝,用于输送naproxen,一种止痛药. 智能水凝保护胃中的药物,并在肠道释放,减少胃肠道副作用.

科学领域:

生物材料科学
聚合物化学
制药科学

背景情况:

纳普罗森是一种有效的止痛药,但可能会引起胃肠道问题.
智能水凝提供了一种策略,通过控制其释放来减轻纳的副作用.
开发有针对性的药物输送系统对于改善治疗结果至关重要.

研究的目的:

准备和优化一种新的基于点的水凝 ((Ptn/PVA) -g-poly ((AA)) 作为纳素的载体.
评估开发的水凝的结构,形态和粘弹性特性.
在模拟的胃肠环境中评估纳普罗从水凝释放的pH敏感性.

主要方法:

将酸聚合在pectin和polyvinyl酒精上以合成水凝.
使用FT-IR光谱,野外发射扫描电子显微镜 (FESEM) 和学测量进行了表征.
在模拟的胃和肠液中进行体外药物释放研究,然后进行动态建模.

主要成果:

已经成功合成和描述了 (Ptn/PVA) -g-poly (AA) 水凝.
水凝表现出对 pH 敏感的行为, 保护模拟胃液中的纳素.
根据Korsmeyer- Peppas和第一阶段模型,在模拟的肠道条件下释放了大约69%的纳普.

结论:

基于点的智能水凝有效地提供纳素,在胃中显示保护性,在肠道中显示受控释放性.
这种水凝系统具有针对性和增强性纳普洛克森药物输送的巨大潜力.
开发的材料提供了一种有希望的方法来减少纳素引起的胃肠道副作用.

关键词:

控制的释放在口服中对于pH敏感

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