与结合组织疾病相关的间歇性肺病的动物模型:现状和未来方向
Ziyi Tang1, Hang Yang2, Xiuping Liang1
1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610093, China.
Autoimmunity reviews
|August 27, 2025
概括
开发特定亚型的临床前模型对于了解结合组织疾病相关的间歇性肺病 (CTD-ILD) 和改善患者治疗结果至关重要. 目前的模型缺乏特异性, 阻碍了针对这个复杂的肺部疾病的个性化治疗方法.
科学领域:
- 肺病学
- 关节病学
- 翻译医学
背景情况:
- 连接组织疾病相关的间歇性肺病 (CTD-ILD) 是连接组织疾病 (CTD) 患者的主要死亡原因.
- 现有的CTD-ILD治疗指南和疗法往往是无效的,原因是对亚型特异性疾病机制的理解不足,以及不针对特定CTD-ILD病理的治疗方法的使用.
- 需要改进的临床前模型,准确反映不同CTD-ILD亚型的异质性和特定致病机制,以促进个性化治疗策略.
研究的目的:
- 对目前用于CTD-ILD研究的动物模型进行审查和批判性评估.
- 突出现有模型在捕捉人类CTD-ILD的复杂性和异质性的局限性.
- 提出新兴技术的整合,以开发下一代特定亚型的临床前模型.
主要方法:
- 对CTD-ILD动物模型的当前文献进行系统审查.
- 对模型构造,特性和局限性的分析.
- 确定现有模型与人类CTD-ILD之间的差异.
- 探索新兴技术,如CRISPR/Cas9,人性化小鼠和有机系统.
主要成果:
- 目前的CTD-ILD动物模型往往无法完全复制在人类患者中观察到的多种亚型和特定的致病机制.
- 已确定的动物模型与相应的人类CTD-ILD之间存在显著的差异,限制了它们的转化价值.
- 新兴技术为创建更准确和更具预测性的临床前模型提供了有希望的途径.
结论:
- 对于CTD-ILD研究和治疗开发来说",一个适合所有人的模型"的方法是不够的.
- 开发特定亚型的临床前模型对于推进CTD-ILD精度医学至关重要.
- 需要关于选择和开发模型的指导,包括既有和新技术,以加快针对性治疗的发现和改善CTD-ILD患者的临床结果.
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