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In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
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Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
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相关实验视频

Updated: Sep 10, 2025

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
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在体外和体内自发高血压小鼠中抑制了人类大动脉间细胞的化

Zaiqiang Yu1, Shihu Men1, Kazuyuki Daitoku1

  • 1Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan.

Journal of pharmacological sciences
|August 27, 2025
PubMed
概括

一种传统的日本草药Oren-gedoku-to通过向瘤死因α (TNF-α) 诱导的途径,有效地抑制了缩性大动脉缩 (CAS) 的进展. 这项研究强调了OGT及其成分贝贝林作为CAS的潜在治疗剂.

关键词:
大动脉间细胞柏柏林动脉狭窄症化奥伦-盖多科

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科学领域:

  • 心血管医学
  • 药理学
  • 传统医学

背景情况:

  • 动脉狭窄症 (CAS) 是发达国家中最常见的成人心脏病.
  • 目前没有可用于CAS的药物治疗方法.
  • 已知瘤死因-α (TNF-α) 通过骨形态蛋白 (BMP) - 2/性酸酶 (ALP) 途径促进大动脉结石化 (AVC).

研究的目的:

  • 调查传统日本草药Oren-gedoku-to (OGT) 在预防TNF-α诱导的AVC和CAS进展方面的治疗潜力.
  • 阐明OGT对AVC作用的基础分子机制.

主要方法:

  • 使用与TNF-α治疗的人类大动脉间细胞 (HAVIC) 的体外研究.
  • 使用自发高血压的老鼠进行体内研究,以评估OGT对加速的AVC的影响.
  • 对BMP2表达,p65 NF-κB酸化和ALP激活的分析.

主要成果:

  • 在HAVIC中,OGT显著抑制了TNF-α诱导的化,而这取决于剂量.
  • OGT抑制了TNF-α诱导的BMP2表达,p65 NF-κB酸化和ALP激活.
  • 特定的OGT成分,Coptis根茎 (CR),Phellodendron树皮 (PB) 和柏柏林,表现出类似的抑制作用.
  • 在自发高血压的老鼠中,OGT的使用防止了加速的AVC.

结论:

  • OGT及其活性成分贝贝林在预防和治疗动脉狭窄方面具有显著的潜力.
  • 这些发现表明OGT和柏柏林是针对TNF-α/ BMP2/ ALP途径的有希望的治疗候选药物.