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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
新型复合指数在预测局部晚期直肠癌全新辅助疗法的有用性:多中心真实世界队列研究

新型复合指数在预测局部晚期直肠癌全新辅助疗法的有用性:多中心真实世界队列研究

Peng Ye ¹, Yizhen Chen ², Fang Ye ³, Weijie Chen ⁴, Zhenyuan Zhou ⁵, Rong Ye ⁶, Hangdong Jia ⁷, Ting Zheng ¹, Chunying Zheng ¹

Peng Ye ¹, Yizhen Chen ², Fang Ye ³

¹Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, China.
²Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, China; Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 350001, China.
³Surgical Anesthesiology Department, Zhongshan Hospital Xiamen University.
⁴Department of Hepatobiliary Pancreatic Surgery, The First Hospital of PuTian City, Putian, Fujian 351100, China.
⁵Anorectal Surgical Department, Hangzhou Red Cross Hospital, Hangzhou, Zhenjiang, China.
⁶Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, China.
⁷General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.

⁰Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, China.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver +

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2025年八月27日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

在接受全新辅助疗法 (TNT) 的局部晚期直肠癌 (LARC) 患者中,C-反应蛋白- 白蛋白- 淋巴细胞 (CALLY) 指数有效预测结果. 较高的CALLY分数表明无病和整体存活率更高,有助于个性化治疗策略.

科学领域

癌症学
临床预测
结直肠癌研究

背景情况

全新辅助治疗 (TNT) 是局部晚期直肠癌 (LARC) 的标准治疗方法.
在接受TNT的LARC患者中,新型C- 反应蛋白- 白蛋白- 淋巴细胞 (CALLY) 指数的预后价值尚未确立.

研究的目的

评估C-反应性蛋白- 白蛋白- 淋巴细胞 (CALLY) 指数作为接受全新辅助治疗的局部晚期直肠癌 (LARC) 患者的预后工具.
评估CALLY指数与治疗结果之间的关联,包括并发症,病理完整反应,无病生存期 (DFS) 和整体生存期 (OS).

主要方法

这是一项多中心实验,涉及995名用TNT治疗的LARC患者.
限制立方脊柱 (RCS) 分析用于确定CALLY指数与各种临床结果之间的关系.
高CALLY (≥13.5) 和低CALLY组之间的DFS和OS的比较.

主要成果

RCS分析显示了CALLY指数与TNT相关的不良事件,术后并发症,DFS和OS之间的线性关联.
高CALLY组的患者与低CALLY组的患者相比,显著改善了DFS和OS (P< 0. 001).
高CALLY组的5年DFS和OS率分别为77.6%和81. 8%,低CALLY组的51. 6%和59. 7%.

结论

对于接受TNT的LARC患者来说,基线CALLY指数是一个有价值的预后指标.
CALLY指数可以帮助指导个性化治疗策略,以改善患者的结果.

关键词:

C反应性蛋白-白蛋白-淋巴细胞局部发达的直肠癌限制立方线全新辅助疗法

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