防止蚊子咬的挥发性甲状体空间驱虫剂:系统审查和元分析
Ingrid Chen1, Sarah L Miller2, Daniel Msellemu3
1Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA; Malaria Elimination Initiative, Institute for Global Health Sciences, University of California, San Francisco, CA, USA.
EBioMedicine
|August 27, 2025
概括
挥发性体空间驱虫剂 (VPSRs) 提供56%的防蚊效果. 人类登陆捕获 (HLC) 提供了最可靠的数据,尽管户外保护需要在特有地区进行进一步研究.
科学领域:
- 医学昆虫学
- 公共卫生
- 载体控制
背景情况:
- 在预防疟疾和登革热等蚊子传播疾病方面, 挥发性甲状腺空间驱逐剂 (VPSR) 是至关重要的.
- 不同的评估方法对VPSR的保护效果产生了不确定性.
- 这次审查巩固了针对各种蚊子物种和测试方法的VPSRPE的昆虫学证据.
研究的目的:
- 系统地审查和对VPSR保护功效的昆虫学证据基础进行元分析.
- 评估PE对阿诺菲莱斯,埃德斯和库莱克斯蚊子.
- 为了比较不同测试方法和设置的有效性.
主要方法:
- 从2000年1月到2023年9月的研究的系统审查和元分析.
- 包括通过人类登陆捕获 (HLC) 或蚊帐密度测量PE的半场和野外研究.
- 集成的蚊子水平和天气数据;按产品,活性成分,捕获方法,物种和环境分析PE.
主要成果:
- 对于蚊子咬伤,VPSR的平均PE值为56%.
- 人类登陆捕获 (HLC) 提供了最高的PE估计值 (58%在半田间,50%在田间研究中).
- 对Anopheles funestus (31%) 观察到较低的PE;在室内和室外环境中有效性是一致的,不受天气的影响.
结论:
- 通过半场和现场数据对齐,VPSR提供了对蚊子接触的重要保护.
- 人类登陆捕获 (HLC) 是评估VPSR有效性的首选方法.
- 在非洲,南美洲和东南亚的疟疾流行地区, 对户外保护的进一步实地研究是必不可少的.
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