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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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相关实验视频

Updated: Sep 10, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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CD99介导的免疫突触形成增强了CAR-T细胞的功能

Giri Nam1,2, Hye Ran Yeon3,4,5, Hyung Bae Park1,3,4,5

  • 1Department of Biomedical Sciences, Seoul National University, Seoul, 03080, Republic of Korea.

Nature communications
|August 27, 2025
PubMed
概括

增强化学抗原受体 (CAR) - T细胞治疗包括改善免疫突触 (IS) 稳定. 将CD99域纳入CAR结构可以提高T细胞对淋巴瘤的疗效.

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科学领域:

  • 免疫学
  • 细胞生物学
  • 癌症治疗

背景情况:

  • 化学抗原受体 (CAR) - T细胞疗法对血液恶性瘤具有前景.
  • 需要进一步优化CAR-T细胞设计以改善治疗结果.

研究的目的:

  • 研究CD99在T细胞免疫突触 (IS) 形成中的作用.
  • 探索将CD99纳入CAR结构的潜力,以提高T细胞的功能和疗效.

主要方法:

  • 通过研究actin-microtubule相互作用来研究CD99在T细胞IS形成中的作用.
  • 在体内评估了CD99缺乏对T细胞免疫力的影响.
  • 具有CD99跨膜和直膜域的工程CAR-T细胞.
  • 对免疫缺陷小鼠的淋巴瘤进行治疗.

主要成果:

  • CD99通过调解actin-microtubule相互作用对IS形成至关重要.
  • 缺少CD99会影响IS的形成和体内T细胞的免疫力.
  • 将CD99域纳入CAR结构可以增强IS的形成.
  • 修改后的CAR- T细胞显示出对淋巴瘤的治疗效果有所改善.

结论:

  • CD99在T细胞IS稳定中起着至关重要的作用.
  • 通过CD99调节的IS稳定是改善CAR- T细胞设计和癌症治疗效能的有希望的策略.