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Updated: Sep 10, 2025

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低氧压力诱导HIF1α驱动的核糖体生物生成,可以通过向RNA聚合酶I来利用

Amr Elhamamsy1, Brandon J Metge1, Courtney A Swain1

  • 1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.

Nature communications
|August 27, 2025
PubMed
概括

低氧诱导因子1-α (HIF1α) 移动到细胞核,促进核糖体RNA的产生. 这种过程促进了癌症的进展和转移, 为乳腺癌治疗提供了新的治疗点.

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