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Updated: Sep 10, 2025

Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells
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通过G41D突变SOD1电荷变化的影响揭示蛋白质聚合过程

Zainab Abdullah Waheed1, Abasalt Hosseinzadeh Colagar2, Bagher Seyedalipour1

  • 1Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran.

Scientific reports
|August 27, 2025
PubMed
概括

人类超氧化脱酶1 (hSOD1) 中的G41D突变导致不稳定和聚合,导致像ALS这样的神经退行性疾病. 了解这些电荷变化为fALS提供了潜在的治疗目标.

关键词:
分子动力学 (MD) 模拟蛋白质聚合一个SOD1错误的链 (β4)

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